NBPF10

Content sourced from Wikipedia, licensed under CC BY-SA 3.0.

NBPF10 (Neuroblastoma breakpoint family member 10) is a human gene that makes a protein in the NBPF family. It sits on chromosome 1 at 1q21.1 and spans about 75,313 base pairs. The major mRNA transcript is about 10,697 nucleotides long.

NBPF genes contain DUF1220 repeats, a feature thought to derive from the ancestral gene MGC8902. The NBPF family is linked to primate evolution and to copy-number changes in the 1q21.1 region, which can be associated with deletion or duplication syndromes.

NBPF10 has paralogs within the NBPF family, and orthologs are found in other primates; distant orthologs appear in cow, horse, and dog.

The exact function of NBPF10 is unknown, but it may be a biomarker for odontoblasts, the tooth-forming cells. Nearby genes such as NOTCH2NL, SEC22B, HFE2, and TXNIP are well studied. The NBPF10 protein has unusually low threonine content, which might affect post-translational modification.