GSTT2

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GSTT2, or glutathione S-transferase theta-2, is an enzyme in humans encoded by the GSTT2 gene. It belongs to the theta class of the glutathione S-transferase family, which helps detoxify harmful compounds by attaching glutathione to them. GSTT2 and its close relative GSTT1 share about 55% amino acid sequence identity and are thought to play a role in cancer development. The gene has five exons with identical exon/intron boundaries. In humans, GSTT2 is located on chromosome 22q11.23; the mouse equivalent is on chromosome 10. It is expressed in many tissues, including the testis, adrenal glands, kidney (proximal tubule), liver, duodenum, and several brain regions. Like other GSTs, GSTT2 helps detoxify electrophiles and hydrophobic compounds as part of the glutathione metabolic pathway.