CAND1
CAND1 stands for Cullin-associated NEDD8-dissociated 1. It is a human protein produced from the CAND1 gene on chromosome 12. Its job is to help regulate cullin-RING ubiquitin ligases (CRLs), which are responsible for tagging other proteins for destruction inside the cell. CAND1 binds to cullin proteins when they are not modified by NEDD8, helping to control the assembly and activity of CRLs and therefore protein turnover.
The CAND1 gene has a mouse counterpart on chromosome 10. The protein is expressed in many tissues, with higher levels reported in certain developing brain regions and in several organs such as the endometrium, ovaries, and blood vessels. CAND1 interacts with Cullin proteins and other parts of the ubiquitin-proteasome system. It is also known by aliases such as TIP120.
This page was last edited on 3 February 2026, at 05:32 (CET).