C1orf185
C1orf185 is a human gene that makes a small protein of about 22 kDa. The protein has a single transmembrane region, a very short extracellular piece at the start, and a longer intracellular tail. The gene sits on chromosome 1 (p32.3) and, in its main splice form, has five exons (a total of five human splice variants).
The protein belongs to a family with a domain of unknown function (DUF4718). It contains a transmembrane segment from amino acids 15 to 37 and a serine-rich region from 123 to 142, which could be involved in splicing regulation. Overall, C1orf185 is expressed at very low levels but has been detected in the circulatory system, particularly in blood.
Expression data suggest C1orf185 is more active in certain blood-related contexts, such as whole blood in some postmenopausal women and in peripheral blood of Parkinson’s patients, although its general expression is weak.
Potential function: C1orf185 is thought to play a role in the circulatory system and may be connected to cardiovascular conditions. Some studies have linked it to atrial fibrillation and abnormal QRS duration, hinting at a reactive or regulatory role in heart biology.
Evolution and conservation: The gene is conserved mainly in mammals and some reptiles. The transmembrane region is the most conserved part across species; primates show higher overall sequence conservation. C1orf185 appears to be evolving relatively quickly.
Other notes: There is a predicted microRNA binding site that could repress the gene after transcription. Structural analyses support a membrane protein with both extracellular and intracellular regions.
This page was last edited on 2 February 2026, at 19:00 (CET).