SKF-83,959
SKF-83,959 is a synthetic benzazepine compound used in scientific research. It acts on dopamine receptors as an agonist at a D1–D2 receptor pair: it is a full agonist at the D1 part and a high-affinity partial agonist at the D2 part. It also modulates the sigma-1 receptor as an allosteric modulator. In addition, SKF-83,959 inhibits sodium channels and delayed rectifier potassium channels. The molecule is a racemate, consisting of two enantiomers: R-(+)-MCL-202 and S-(−)-MCL-201. It has been described as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). The synthesis has been reported in the scientific literature.
Chemical data:
- IUPAC name: 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
- CAS number: 67287-95-0
- Molecular formula: C18H20ClNO2
- Molecular weight: 317.81 g/mol
This page was last edited on 2 February 2026, at 20:22 (CET).