Bromisoval

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Bromisoval, also known as bromovalerylurea, is a sedative drug in the bromoureide group. It was discovered by Knoll in 1907 and patented in 1909.

Where it is used
- In parts of Asia, bromisoval is sold over the counter under various brand names (for example, Brovarin).
- It is often sold in combination with nonsteroidal anti-inflammatory drugs (NSAIDs).

Safety
- Long-term use can lead to bromine poisoning.

What it is and how it is made
- Chemical type: a brominated urea derivative.
- IUPAC name: (RS)-2-Bromo-N-carbamoyl-3-methylbutanamide.
- Chemical formula: C6H11BrN2O2; molar mass about 223 g/mol.

How it is prepared
- It is made by brominating isovaleric acid using the Hell-Volhard-Zelinsky reaction, then reacting the product with urea.