Brain-specific angiogenesis inhibitor

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Brain-specific angiogenesis inhibitors (BAI1, BAI2, BAI3) are a small family of proteins that sit in the cell membrane as G protein-coupled receptors. They belong to the class B secretin receptor family and are mainly found in the brain, where they help regulate the growth of blood vessels (angiogenesis). Each member is produced from its own gene on a different chromosome:
- BAI1: chromosome 8, region q24
- BAI2: chromosome 1, region p35
- BAI3: chromosome 6, region q12

These are transmembrane receptors, and scientists are still learning exactly how they control brain blood vessel formation.