3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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3-Galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase (EC 2.4.1.65) is an enzyme that adds a fucose sugar to a specific galactosyl-N-acetylglucosaminide-containing molecule. It uses GDP-beta-L-fucose as the donor and the acceptor is beta-D-galactosyl-(1→3)-N-acetyl-D-glucosaminyl-R. In the reaction, GDP is released and a fucosylated product is formed: beta-D-galactosyl-(1→3)-[alpha-L-fucosyl-(1→4)]-N-acetyl-beta-D-glucosaminyl-R. This enzyme participates in three biosynthetic pathways: glycosphingolipid biosynthesis – lactoseries, glycosphingolipid biosynthesis – neo-lactoseries, and glycan structures – biosynthesis 2. It belongs to the glycosyltransferase family, specifically hexosyltransferases. The systematic name is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4-alpha-L-fucosyltransferase.