TAFA5

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TAFA5 (also known as FAM19A5) is a small secreted protein made from the TAFA5 gene in humans. It belongs to the TAFA family of five genes and is only distantly related to the CC-chemokine family. TAFA proteins have conserved cysteine residues and are thought to act as brain-specific chemokines or neurokines, helping regulate immune and nerve cells.

Where it’s found
- Human TAFA5 is on chromosome 22 (22q13.32).
- The mouse version is the ortholog on chromosome 15.

What it does
- TAFA5 is mainly expressed in the brain and is believed to help coordinate signaling between immune cells and neurons, supporting brain function.

Expression patterns
- In both humans and mice, TAFA5 shows high expression in several brain regions, including parts of the cortex, hippocampus, amygdala, hypothalamus, cerebellum, and midbrain areas.