RNGTT

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RNGTT is a human gene that makes the RNA capping enzyme, a key protein in preparing messenger RNA (mRNA) for use in the cell. The enzyme is also known by aliases such as CAP1A, HCE, and hCAP. Its main job is to add a protective cap to newly formed mRNA, which helps stabilize the molecule, export it from the nucleus, and enable proper protein production.

RNGTT belongs to the mRNA capping machinery and has several related activities: it acts as an RNA triphosphatase, a guanylyltransferase that adds the cap, and it also has 5'-phosphatase-related activities. This combination of functions makes RNGTT essential for initiating efficient gene expression.

In the human genome, RNGTT is located on chromosome 6 at band q15. The mouse equivalent (ortholog) is on chromosome 4. RNGTT is expressed in many tissues in both humans and mice, reflecting its broad role in RNA processing throughout the body.