Pantoate—beta-alanine ligase

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Pantoate—β-alanine ligase (EC 6.3.2.1) is an enzyme that helps make pantothenate (vitamin B5) in cells. It uses ATP to join (R)-pantoate and β-alanine into pantothenate, releasing AMP and diphosphate in the process. This reaction forms a carbon–nitrogen bond and belongs to the ligase family. The systematic name is (R)-pantoate:β-alanine ligase (AMP-forming). It is also known as pantothenate synthetase or pantoate-activating enzyme and participates in beta-alanine metabolism and the biosynthesis of pantothenate and coenzyme A. Many three-dimensional structures have been solved and are available in structural databases.