LITAF

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LITAF stands for lipopolysaccharide-induced TNF factor. It is a human gene that makes a protein involved in controlling the body's inflammatory response, especially the production of tumor necrosis factor (TNF) when bacteria are detected.

The LITAF protein helps regulate gene activity in response to inflammatory signals. It can bind to DNA and interact with other proteins to influence transcription. The protein also associates with cellular membranes and endosomes, placing it in the cytoplasm and near places where proteins are processed inside the cell.

In humans, the LITAF gene is located on chromosome 16 at position 16p13.13 (about 11.55 to 11.64 million base pairs). The mouse LITAF gene is found on chromosome 16.

LITAF is expressed in many tissues, with higher activity in blood and certain immune-related cells, among other tissues.

Mutations in LITAF cause Charcot–Marie–Tooth disease type 1C (CMT1C), a hereditary nerve disorder that affects the peripheral nerves, leading to weakness, numbness, and muscle wasting in the limbs.

In short, LITAF helps manage inflammatory signals and, when altered, can contribute to a genetic nerve disease.