IFT20

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IFT20 is a human gene that encodes intraflagellar transport protein 20. This protein is part of the intraflagellar transport (IFT) system that builds and maintains cilia and flagella, the small projections on cells used for movement, sensing, and development. The IFT20 gene has six exons and is located on chromosome 17. The protein localizes to the Golgi apparatus and to the base of the cilium, and it moves along ciliary microtubules, shuttling between the Golgi and the cilium. In the testis, IFT20 interacts with SPEF2 and helps sperm motility. IFT20 is expressed in several tissues, with the highest levels in the brain, lung, kidney, and pancreas; lower levels are found in placenta, liver, thymus, prostate, and testis. The protein participates in various cellular processes, including cilium assembly and function, and it is involved in signaling pathways that influence development and organ function.