BIM-1
BIM-1 is a laboratory chemical that blocks certain enzymes called protein kinases, mainly PKC (protein kinase C) isoforms, with a preference for PKC iota. It also inhibits PDK1, which helps explain why some BIM compounds can be particularly potent.
How it works: BIM-1 binds to the ATP-binding site of PKC, acting as an ATP-competitive inhibitor. This prevents the kinase from transferring phosphate groups in cellular signaling pathways.
Quick facts:
- Synonyms: GF 109203X; BIM-1
- CAS number: 133052-90-1
- DrugBank: DB03777; PubChem: 2396
- Molecular formula: C25H24N4O2; Molar mass: 412.49 g/mol
- Appearance: orange solid; Melting point: 208–210 °C; Solubility: soluble in DMSO
Related compounds: BIM-2, BIM-3, BIM-8.
This page was last edited on 2 February 2026, at 02:46 (CET).