U46619

Content sourced from Wikipedia, licensed under CC BY-SA 3.0.

U46619 is a stable synthetic compound that imitates the natural prostaglandin PGH2. It was first made in 1975. It acts as an agonist of the thromboxane A2 (TP) receptor, meaning it activates this receptor to produce effects similar to thromboxane A2. In laboratory tests, U46619 mainly triggers TP receptor–mediated responses and not other prostaglandin receptors. It causes platelets to change shape and clump together (platelet aggregation) and it can contract smooth muscle. It is also a vasoconstrictor and can mimic some water-retaining effects of vasopressin. Researchers use it to study blood clotting, blood vessel constriction, and related processes.