Tametraline
Tametraline (CP-24,441) is a chemical studied by Pfizer that helped lead to the antidepressant sertraline. It acts as a norepinephrine–dopamine reuptake inhibitor, meaning it blocks the reabsorption of the brain chemicals norepinephrine and dopamine, increasing their levels.
The active form is the 1R,4S stereoisomer, known as 1R-methylamino-4S-phenyl-tetralin. In tests with animals, this compound inhibits norepinephrine uptake in rat brain tissue, reverses reserpine-induced hypothermia in mice, and blocks the uptake of norepinephrine into rat heart tissue.
Sertraline is related to tametraline but is specifically the S,S isomer. Describing sertraline as simply “3,4-dichloro-tametraline” is an oversimplification. Indatraline is another related compound in the same family, an indanamine derivative of tametraline.
This page was last edited on 2 February 2026, at 15:32 (CET).