TAS2R9

Content sourced from Wikipedia, licensed under CC BY-SA 3.0.

TAS2R9 is a human gene that encodes a bitter taste receptor, part of the TAS2R family of G protein-coupled receptors. It is expressed in the taste receptor cells of the tongue and palate, helping detect bitter compounds.

Where TAS2R9 is located:
- Chromosome 12, region 12p13.2
- GRCh38 coordinates: start 10,809,094 bp, end 10,810,168 bp
- Also known by aliases: TAS2R9, T2R9, TRB6
- Orthologs exist in other species, including mice

What TAS2R9 does:
- It is a member of a gene cluster involved in bitter taste perception.
- When activated by bitter compounds, it triggers a G protein-coupled signaling pathway that leads to the sensation of bitterness.

Genetic variation and taste:
- Polymorphisms in TAS2R9 have been linked to differences in how bitter people perceive certain sweeteners, such as acesulfame potassium.

Transcripts and proteins:
- Human mRNA: NM_023917
- Protein: UniProt entry Q9NYW1

See also:
- Taste receptor
- Bitter taste receptors (TAS2R family)