SPATA5

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SPATA5 (spermatogenesis-associated protein 5) is a human gene that makes a protein important for sperm development. The SPATA5 protein can bind and use ATP, indicating a role in cellular energy and activity, and is located in the cytoplasm and mitochondria.

Key facts:
- Location: Human chromosome 4, band 4q28.1 (about 122.92–123.32 million bases). The mouse version is on chromosome 3 in a similar region.
- Function: Binds ATP and has ATPase activity; acts as a hydrolase involved in cellular energy use.
- Role: Associated with spermatogenesis (formation of sperm) and also involved in broader developmental processes like brain development.
- Expression: Most active in testis, with expression in various tissues and during germ cell and embryonic development.
- Aliases: AFG2, SPAF, EHLMRS, spermatogenesis associated 5, NEDHSB.
- Related identifiers: OMIM 613940; MGI 1927170; UniProt Q8NB90; Ensembl human ENSG00000145375; Ensembl mouse ENSMUSG00000027722.