Nucleoside deoxyribosyltransferase

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Nucleoside deoxyribosyltransferase (EC 2.4.2.6) is an enzyme that swaps the sugar part of nucleosides. It transfers a deoxyribose from one nucleoside to another base, catalyzing the reaction: 2-deoxy-D-ribosyl-base1 + base2 -> 2-deoxy-D-ribosyl-base2 + base1. The enzyme belongs to the glycosyltransferase family, specifically pentosyltransferases. It is often a homohexamer in Lactobacillus leichmannii. This enzyme participates in pyrimidine metabolism and can act on both purine and pyrimidine bases. Structural studies have solved about a dozen structures for this enzyme, with PDB entries such as 1F8X, 1F8Y, 1S2D, 1S2G, 1S3F, 2A0K, 2F2T, 2F64, and 2F67.