List of SJS-inducing substances

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Substances that can cause Stevens-Johnson Syndrome (SJS)

Stevens-Johnson syndrome is a rare but serious reaction that affects the skin and mucous membranes. It is often triggered by certain medicines. It usually starts with fever and flu-like symptoms, then a painful, spreading red or purplish rash with blisters. SJS can be life-threatening and needs urgent medical care.

Common drug triggers include:

- Anti-seizure medicines: carbamazepine, lamotrigine, phenobarbital, valproic acid (less commonly)
- Antibiotics: sulfonamides (sulfamethoxazole-trimethoprim), penicillins (amoxicillin, ampicillin), cephalosporins; fluoroquinolones (ciprofloxacin, levofloxacin)
- Allopurinol (used for gout)
- Nonsteroidal anti-inflammatory drugs (NSAIDs): especially the older oxicam-type like piroxicam; other NSAIDs have also been linked
- HIV medicines: nevirapine
- Dapsone

What to do:

- If you have fever with a widespread painful rash or blistering, seek urgent medical care immediately.
- Do not stop a prescribed medicine on your own. Talk to your doctor before stopping or changing any drug.
- Tell your doctors about any past reactions to medicines, including SJS.