ILKAP

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ILKAP (Integrin-linked kinase-associated serine/threonine phosphatase 2C) is an enzyme in humans encoded by the ILKAP gene. It belongs to the PP2C family and acts as a protein serine/threonine phosphatase. ILKAP binds to integrin-linked kinase (ILK) and helps regulate ILK’s activity, which affects signals that control how cells attach to their surroundings. By interacting with ILK, ILKAP can influence the signaling pathway involving glycogen synthase kinase 3 beta (GSK3β) and the Wnt signaling pathway, which are important for development and cellular communication. ILKAP is expressed in many tissues, with notable levels in the cerebellum, pituitary, thyroid, and other organs. The human ILKAP gene is located on chromosome 2q37.3 (the mouse version is on chromosome 1). Other names for ILKAP include ILKAP2, ILKAP3, PP2C-DELTA, and PPM1O.