GSTA2

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GSTA2 is a human gene that makes an enzyme called glutathione S-transferase A2. It belongs to the alpha class of the glutathione S-transferase (GST) family, a group of enzymes that protect cells by detoxifying harmful compounds. They do this by attaching glutathione to carcinogens, environmental toxins, and byproducts of oxidative stress, helping remove them from the body.

The GSTA2 gene is located on chromosome 6 (6p12.2). Alpha-class GST enzymes are especially abundant in the liver, where they help metabolize bilirubin and some anti-cancer drugs, and they may also shield cells from oxidative damage.

GSTA2 and other GST genes have many natural genetic variants. These variants can influence how strongly someone detoxifies toxins, their cancer risk, and how they respond to certain drugs.

GSTA2 is expressed in several tissues, with high levels in the liver and notable activity in the pancreas, duodenum, and some other organs.