Fixed-dose procedure

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Fixed-dose procedure (FDP) is a test designed to estimate a substance's acute oral toxicity. It was proposed in 1992 by the British Toxicology Society. Compared with the older LD50 test from 1927, FDP yields similar results but uses fewer animals and causes less pain and suffering. In 1992, the Organisation for Economic Co-operation and Development endorsed FDP as an alternative to LD50 under OECD Test Guideline 420. The U.S. Food and Drug Administration has started approving non-animal testing methods in response to cruelty concerns and questions about how well animal tests predict human toxicity.