CYP2A13
CYP2A13 is a human gene that makes an enzyme in the cytochrome P450 family. These enzymes are monooxygenases that help metabolize drugs and synthesize lipids by adding oxygen to chemicals. CYP2A13 is located in the endoplasmic reticulum of cells.
This enzyme can metabolize a range of compounds and is known to process a major tobacco-specific nitrosamine called NNK, a chemical linked to tobacco use. The endogenous substrate of CYP2A13 has not been determined.
CYP2A13 sits on chromosome 19q13.2 in humans and is part of a cluster of related cytochrome P450 genes (CYP2A, CYP2B, and CYP2F). The mouse counterpart (ortholog) is on chromosome 7.
Expression-wise, CYP2A13 is found in several tissues, with higher levels in nasal and olfactory tissues, kidneys, liver, and parts of the respiratory tract.
This page was last edited on 3 February 2026, at 15:03 (CET).