2012 Bank of the West Classic – Singles

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Serena Williams defended her title at the 2012 Bank of the West Classic in singles, defeating lucky loser CoCo Vandeweghe in the final 7–5, 6–3. This was the first all-American final on the WTA Tour since 2009, and the first on American soil since 2004 in Los Angeles. The tournament had a 28-player draw with 8 seeds, and the top four seeds received byes into the second round.