2-Oleoylglycerol
2-Oleoylglycerol (2OG) is a small lipid found in body tissues. It is a monoacylglycerol, meaning glycerol with one oleoyl (oleic) acid attached. It is formed from diacylglycerol precursors in cells and is mainly broken down into oleic acid and glycerol by the enzyme monoacylglycerol lipase (MAGL).
Why it matters:
- In 2011, 2OG was identified as an endogenous ligand of the receptor GPR119.
- When given to the small intestine, 2OG increases the levels of the hormones GLP-1 and GIP, which help regulate glucose.
- It can modulate signaling at the serotonin 5-HT2A receptor by binding allosterically, boosting G protein signaling without activating β-arrestin pathways.
This page was last edited on 2 February 2026, at 14:53 (CET).