COX18, cytochrome c oxidase assembly factor
COX18, cytochrome c oxidase assembly factor
COX18 is a human gene that makes a mitochondrial protein important for building cytochrome c oxidase (Complex IV), a key enzyme in the cell’s energy-producing machinery. The COX18 protein sits in the inner membrane of mitochondria and helps insert other proteins into the membrane, a necessary step for assembling and activating cytochrome c oxidase.
Where it’s found
- In humans, COX18 is located on chromosome 4 (region 4q13.3). The mouse version is on chromosome 5.
- The gene can produce multiple transcript variants through alternative splicing.
What it does
- The protein acts as a membrane insertase and assembly factor, essential for the proper assembly and function of cytochrome c oxidase in the mitochondrial inner membrane.
- By supporting Complex IV assembly, COX18 helps ensure efficient cellular energy production.
Expression
- COX18 is expressed in many tissues, reflecting its broad role in mitochondrial energy metabolism.
This page was last edited on 3 February 2026, at 18:41 (CET).