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2,3-dihydroxybenzoate—serine ligase

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Enterobactin synthase (2,3-dihydroxybenzoate—serine ligase) is an enzyme used by some bacteria to build enterobactin, a molecule that helps them grab iron from the environment. It uses ATP to join 2,3-dihydroxybenzoate with the amino acid L-serine, forming the compound N-(2,3-dihydroxybenzoyl)-L-serine and releasing AMP and pyrophosphate. This enzyme is a member of the ligase family that forms carbon–nitrogen bonds, also known as acid-D-amino-acid ligases or peptide synthases. Systematic name: 2,3-dihydroxybenzoate:L-serine ligase. Other common names include N-(2,3-dihydroxybenzoyl)-serine synthetase and 2,3-dihydroxybenzoylserine synthetase.


This page was last edited on 2 February 2026, at 08:48 (CET).