ZMYM3

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ZMYM3 is a human gene on the X chromosome that encodes the zinc finger MYM-type protein 3. The protein has three MYM-type zinc finger domains and mainly works in the nucleus as a DNA-binding transcription factor that helps regulate transcription by RNA polymerase II. It is involved in development and in shaping the cell’s cytoskeleton.

In both humans and mice, ZMYM3 is widely expressed. It shows higher levels in the adrenal glands, adrenal cortex, endothelial cells, and ovaries, and is also present in many brain regions (including parts of the retina, frontal cortex, visual cortex, hippocampus, cerebellum, and hypothalamus) as well as in embryonic tissues.

Genetically, ZMYM3 is located on the X chromosome (human Xq13.1). The mouse counterpart is also on the X chromosome. The gene has orthologs in other species, reflecting its conserved role.