T(11:14)

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t(11;14) is a chromosomal translocation that usually involves the IGH gene on chromosome 14 (q32) and the cyclin D1 gene on chromosome 11 (q13). The notation is t(11;14)(q13;q32). This genetic change is most often seen in mantle cell lymphoma, but it also occurs in several other B‑cell cancers, including B‑cell prolymphocytic leukemia, plasma cell leukemia, splenic lymphoma with villous lymphocytes, chronic lymphocytic leukemia, and multiple myeloma. The translocation activates cyclin D1, promoting cancer cell growth. In multiple myeloma, t(11;14) is generally not a strong predictor of outcome, but it may be associated with shorter overall survival in African American patients.