Iso-THIP

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Iso-THIP (also called isoTHIP or Isogaboxadol) is a chemical that blocks the GABAA-ρ receptor (also known as GABAC). It is a selective and potent antagonist for this receptor, about four times stronger than gaboxadol (THIP) at blocking GABAA-ρ. It also has much weaker affinity for the GABAA receptor, where it acts as an antagonist as well. Iso-THIP was first described in 1979 by Povl Krogsgaard-Larsen and colleagues.

Chemical data:
- Molecular formula: C6H8N2O2
- Molar mass: 140.142 g/mol
- SMILES: C1CNCC2=C1C(=O)ON2

Identifiers:
- CAS: 71233-27-7
- PubChem: 130546

Note: It has no ATC code.