Interferon-induced transmembrane protein 5
Interferon-induced transmembrane protein 5 (IFITM5), also known as BRIL, is a small membrane protein that helps bone mineralization. In humans, the gene sits on chromosome 11p15.5 and is about 1,327 bases long, encoding a 132‑amino‑acid protein with a mass of roughly 14 kDa. The protein crosses the cell membrane twice and interacts with FKBP11. IFITM5 is most highly expressed in bone tissue, especially in osteoblasts, the cells that form bone. The mouse version is on chromosome 7. Mutations in IFITM5 cause osteogenesis imperfecta type 5, a brittle-bone disease. Although located near a cluster of interferon-inducible genes, IFITM5 itself is not strongly induced by interferon.
This page was last edited on 2 February 2026, at 20:43 (CET).