Integrin alpha D
Integrin alpha-D
Integrin alpha-D is a human protein produced from the ITGAD gene. It is one part of a family of proteins called integrins, which help cells stick to each other and to the surrounding material. ITGAD pairs with the beta-2 subunit (CD18) to form the integrin known as alpha-D beta-2 (CD11d/CD18).
What it does
ITGAD sits on certain white blood cells (leukocytes) and helps them move from the bloodstream into tissues during immune responses. It acts as a leukocyte adhesion receptor, binding to molecules such as VCAM-1 to help immune cells cling to blood vessel walls and pass into sites of inflammation. It also participates in signaling inside the cell, influencing how the immune system responds.
Where it is and how it’s located
The ITGAD gene is located on human chromosome 16, in the 16p11.2 region. The protein is expressed in several tissues, with high activity in immune cells like granulocytes, and detectable expression in organs such as the spleen and lymph nodes. A mouse version of the gene shows a similar pattern of expression.
Other names and references
ITGAD is also known as ADB2 and CD11D. In UniProt, the human protein is listed as Q13349, and the mouse version as Q3V0T4. ITGAD is linked to various gene and protein databases and research on immune cell adhesion and signaling.
This page was last edited on 1 February 2026, at 20:00 (CET).