GTF3C5

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GTF3C5 is a human protein that is part of transcription factor IIIC (TFIIIC), which helps RNA polymerase III start the production of small RNAs such as tRNAs and 5S rRNA. The GTF3C5 gene is located on chromosome 9 (9q34.13). In the TFIIIC complex, GTF3C5 works together with other subunits, notably GTF3C2 and GTF3C4, to recognize promoters and assemble the preinitiation complex for transcription. The protein functions in the nucleus and is involved in RNA polymerase III–dependent transcription. GTF3C5 has mouse orthologs on chromosome 2 and is expressed in many tissues, with higher levels in some areas such as the cerebellum and certain reproductive and endocrine tissues. Other names for GTF3C5 include TFIIIC63 and TFIIICepsilon.