Bacillus subtilis type I antitoxin SR6

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SR6 is a 100-nucleotide antisense RNA that acts as an antitoxin in Bacillus subtilis. It overlaps two toxin genes: the 3' end of yonT and the 5' end of yoyJ. In type I toxin-antitoxin systems, the antitoxin is a small RNA that neutralizes a toxin protein. Several type I TA systems have been described in B. subtilis. The YonT/SR6 system sits on the SPβ prophage in the B. subtilis chromosome and responds to multiple stresses. SR6 promotes the degradation of yonT mRNA, helping to neutralize the YonT toxin. It may regulate the second toxin, yoyJ, by a different mechanism.