Annexin A6

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Annexin A6 is a calcium‑dependent protein produced from the ANXA6 gene in humans. It belongs to the annexin family, a group of proteins that bind calcium and phospholipids to help membranes during secretion and uptake. The ANXA6 gene is about 60 kilobases long with 26 exons, located on chromosome 5q33.1. The protein is about 68 kilodaltons and consists of eight repeats; there are two isoforms due to alternative splicing of exon 21, differing by a six‑amino‑acid insertion at the start of the seventh repeat. Annexin A6 is involved in endosome clustering and vesicle fusion during exocytosis in secretory epithelia and other cells. It interacts with RAS p21 protein activator 1, linking it to RAS signaling. ANXA6 is expressed in many tissues, with notable levels in granulocytes, smooth muscle, heart, and other areas.