ZNF350

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ZNF350 (also known as ZBRK1 or ZFQR) is a human gene that encodes zinc finger protein 350. This protein binds to DNA and helps regulate gene expression by acting as a transcriptional repressor, particularly for RNA polymerase II–driven transcription. It functions in the cell nucleus as part of transcription repressor complexes and is involved in regulating transcription.

ZNF350 interacts with BRCA1, a key protein in DNA repair, linking it to the cellular response to DNA damage. The gene is located on chromosome 19 at the 19q13.41 region (about 51.96 to 51.99 million base pairs).

The protein is expressed in many tissues, with higher levels in some areas such as the Achilles tendon and various blood-related tissues (including monocytes, bone marrow, and granulocytes). An ortholog exists in mouse, indicating a conserved function across species.