Mannose-1-phosphate guanylyltransferase

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Mannose-1-phosphate guanylyltransferase (EC 2.7.7.13) is an enzyme that helps cells build GDP-mannose, a key sugar building block used in various biosynthetic processes.

Reaction: It uses two substrates—GTP (guanosine triphosphate) and alpha-D-mannose-1-phosphate—and produces two products: diphosphate (pyrophosphate) and GDP-mannose.

Enzyme family and names: This enzyme belongs to the transferases family, specifically nucleotidyltransferases that move nucleotide-containing groups. Its systematic name is GTP:alpha-D-mannose-1-phosphate guanylyltransferase. It is also known as GTP-mannose-1-phosphate guanylyltransferase or GDP-mannose pyrophosphorylase.

Role and structure: It participates in fructose and mannose metabolism. As of 2007, one protein structure had been solved for this class, with the PDB code 2CU2.