JKAMP

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JKAMP (JNK1-associated membrane protein)

JKAMP is a human gene that codes for a membrane protein involved in cellular protein quality control. It has several alternative names, including C14orf100, HSPC213, HSPC327, JAMP, CDA06, JNK1/MAPK8-associated membrane protein, C24orf100, and JNK1/MAPK8 associated membrane protein.

Where it is located
- In humans, JKAMP sits on chromosome 14 at band 14q23.1.
- In mice, the similar gene is found on chromosome 12.
- The human gene has the Ensembl ID ENSG00000050130; the mouse ortholog is ENSMUSG00000005078.

What the protein does
- JKAMP is a membrane protein associated with the endoplasmic reticulum.
- It can bind ubiquitin ligases, linking it to protein degradation pathways inside the cell.

Biological role
- It is thought to participate in the ubiquitin-dependent ER-associated degradation (ERAD) pathway, which helps remove misfolded or damaged proteins from the endoplasmic reticulum.

Expression in tissues
- JKAMP is expressed in many tissues. Notable expression is found in the islets of Langerhans (pancreas), retinal pigment epithelium, various brain regions (including the facial motor nucleus and substantia nigra), as well as in heart tissue, skin, and certain blood vessels.

Why it matters
- As a membrane protein involved in protein quality control, JKAMP may play a role in how cells manage stressed or misfolded proteins, which is important for cell health and could be relevant to diseases that involve protein misfolding.