Hydroxyacid oxidase (glycolate oxidase) 1
Hydroxyacid oxidase 1 (glycolate oxidase 1) is a human enzyme produced from the HAO1 gene. It is located in peroxisomes, small compartments inside cells, and is most active in the liver and pancreas. This enzyme is part of a family that uses oxygen to oxidize hydroxy acids. Its main job is to convert glycolate (a two-carbon molecule) into glyoxylate, and it can also convert glyoxylate into oxalate. It can act on other 2-hydroxy fatty acids as well. These reactions are part of glycolate and fatty acid metabolism and are related to how oxalate is formed, which can be involved in the toxicity of substances like ethylene glycol. The HAO1 gene is located on chromosome 20 in humans. There are related genes in humans and other species with similar activity, but they differ in sequence and where they are expressed.
This page was last edited on 2 February 2026, at 08:02 (CET).