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Galactose-3-O-sulfotransferase

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Galactose-3-O-sulfotransferases are a group of mammalian enzymes that add a sulfate group to the 3' position of galactose in the sugar unit N-acetyllactosamine, found on both O- and N-linked glycans. This sulfation can affect how glycoproteins and glycolipids function and interact. The family includes GAL3ST1, GAL3ST2, GAL3ST3, GAL3ST4, and GP3ST. They belong to the Pfam PF06990 and InterPro IPR009729 families, and there are known protein structures in public databases as well as AlphaFold models for these proteins.


This page was last edited on 2 February 2026, at 14:09 (CET).