GPR37L1
GPR37L1 is a human gene that encodes a transmembrane G protein-coupled receptor related to endothelin receptors. The protein is known as Endothelin B receptor-like protein 2 and functions as a GPCR that helps transmit signals from outside the cell to its interior.
Location: In humans, GPR37L1 is on chromosome 1 at band q32.1. The mouse equivalent is on chromosome 1 as well, showing it is conserved across mammals.
Expression: GPR37L1 is expressed in many tissues, with strong levels in the brain. In both humans and mice, high expression is seen in areas such as the caudate nucleus, putamen, amygdala, nucleus accumbens, globus pallidus, and other basal ganglia structures; it is also prominent in the cerebellum (including the vermis) and brainstem. It is found in endothelial cells and buccal mucosa too.
What it does: As a GPCR, GPR37L1 binds peptide signals and activates intracellular G protein signaling pathways. It is linked to processes like cerebellar development, neuron differentiation, and various signaling cascades (including MAPK). Some related functions may involve regulation of blood pressure.
Orthologs: GPR37L1 has a mouse counterpart, reflecting its conservation across mammals.
In short, GPR37L1 is a brain-active receptor that participates in key signaling pathways and development, with a conserved role across mammals.
This page was last edited on 2 February 2026, at 16:17 (CET).