DEFB127

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DEFB127, or beta-defensin 127, is a human gene that makes a secreted antimicrobial peptide. Defensins are small, cysteine-rich proteins that help defend the body against microbes. The DEFB127 peptide is part of the beta-defensin family and contributes to the body's innate immune defense.

Gene location and family: DEFB127 sits on chromosome 20 at band p13, within a cluster of beta-defensin genes.

Expression: It is expressed in several tissues, with high levels in the epididymis (across various regions) and also detected in the mucosa of the ileum, kidney, skin, and other tissues.

Function: The peptide participates in antimicrobial defense, helping protect mucosal surfaces and other tissues from bacterial infection as part of the innate immune response.