Cyclopropylmescaline

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Cyclopropylmescaline (CPM)

What it is
- A psychedelic drug related to mescaline, in the phenethylamine family. It is taken by mouth.

How long it lasts
- Effects typically last about 12–18 hours.

How it starts and peaks
- Onset is quick, usually within 20 minutes, with peak effects around 1–2 hours after dosing.

Potency
- CPM is about five times as potent as mescaline and lasts longer.

What people experience
- Strong closed-eye visuals and vivid mental imagery often synced to music.
- Less noticeable open-eye visuals.
- Heightened tactile awareness and daydreaming (including erotic themes).
- Some people feel exposed or vulnerable; sounds or voices can feel intrusive.
- Sleep can be affected due to the long duration of the experience.

How it works in the brain
- CPM acts as a full agonist at serotonin 5-HT2 receptors, especially 5-HT2A, and also 5-HT2B and 5-HT2C.

Similar substances
- Related to mescaline and other mescaline-like compounds (escaline, proscaline, allylescaline, methallylescaline, cycloproscaline).

History
- Described by Alexander Shulgin and discussed in PiHKAL (Phenethylamines I Have Known and Loved) in the 1990s.

Legal status
- As of 2025, CPM is not a controlled substance in Canada.