Alanine—glyoxylate transaminase

Content sourced from Wikipedia, licensed under CC BY-SA 3.0.

Alanine-glyoxylate transaminase (AGT) is an enzyme that helps move amino groups between amino acids. In humans, it exists as a dimer. It catalyzes the reaction: L-alanine + glyoxylate ⇌ pyruvate + glycine. It belongs to the transferase family, specifically transaminases. Systematic name: L-alanine:glyoxylate aminotransferase. Other names: AGT, alanine-glyoxylate aminotransferase, alanine-glyoxylic aminotransferase, and L-alanine-glycine transaminase. It participates in alanine and aspartate metabolism and in glycine, serine and threonine metabolism. The enzyme uses pyridoxal phosphate (PLP) as a cofactor. Several 3D structures have been solved, with PDB entries including 1H0C, 1J04, 1VJO, 2BKW, 2HUF, 2HUI, and 2HUU.