ADARB2

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ADARB2, also known as RNA editing deaminase-2 (RED2) or ADAR3, is a member of the double-stranded RNA (dsRNA) adenosine deaminase family. Enzymes in this family typically edit RNA by converting adenosine to inosine, which can change the resulting protein. However, ADARB2 has not shown RNA editing activity in laboratory tests and is thought to act as a negative regulator of RNA editing, potentially by modulating the activity of other ADAR enzymes like ADAR1 and ADAR2.

In humans, the ADARB2 gene is located on chromosome 10p15.3. The mouse equivalent sits on chromosome 13. The protein is mainly expressed in the brain, with high levels in regions such as the substantia nigra, amygdala, hippocampus, and parts of the cortex.