SLC23A2
SLC23A2 (SVCT2) is a human gene that makes a vitamin C transporter protein. It is part of the solute carrier family and uses sodium ions to move ascorbic acid (vitamin C) into cells. It is one of two sodium-dependent vitamin C transporters in the body; the other is SLC23A1 (SVCT1). Together, these transporters help the body absorb vitamin C and deliver it to tissues.
Where it’s found and what it does: SLC23A2 is expressed in many tissues, with notable levels in the adrenal glands and various brain regions, as well as in the choroid plexus and liver. The protein is located in the plasma membrane and other cell membranes, functioning to transport vitamin C into cells.
Genetics: In humans, the SLC23A2 gene is on chromosome 20 (20p13). The mouse version is on chromosome 2. The protein is a membrane transporter that moves L-ascorbic acid into cells and is involved in sodium ion transport and antioxidant protection.
Why it matters: Vitamin C is essential for protecting cells from oxidative stress and for collagen formation. SVCT2 helps ensure tissues receive enough vitamin C, influencing how vitamin C is distributed throughout the body. Problems with this transporter can affect vitamin C uptake and tissue levels.
Aliases and notes: SLC23A2 is also known as SVCT2. It was previously given the symbol SLC23A1 in some records.
This page was last edited on 2 February 2026, at 12:52 (CET).