SEMA3C

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Semaphorin-3C (SEMA3C) is a human protein produced from the SEMA3C gene. It belongs to the semaphorin family, which helps guide growing nerve cells and influences how cells move during development. SEMA3C works by binding to receptors on cell surfaces called neuropilins and plexins, and it can act as a chemorepellent, steering cells away from certain areas.

The SEMA3C gene is located on chromosome 7 at band 7q21.11 in humans (with a corresponding mouse gene on chromosome 5). This gene is active in a variety of tissues, including the eye (retina), lung, skin, salivary glands, and parts of the reproductive system, among others. It plays a role in several developmental processes, such as nervous system development, limb and heart formation, and the growth and remodeling of blood vessels. In short, SEMA3C helps direct the growth of nerves and other cells during development through semaphorin-plexin signaling.