MIS18A

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MIS18A is a human gene that makes the protein Mis18-alpha, a key player in centromere assembly during cell division. It is also known as MIS18alpha, hMis18alpha, MIS18 kinetochore protein A, and by aliases B28, C21orf45, C21orf46, and FASP1.

Location and size:
- Human: chromosome 21, band q22.11 (coordinates 32,268,228–32,279,049 bp)
- Mouse: chromosome 16, band C3.3 (coordinates 90,516,200–90,524,292 bp)

Function:
- Mis18-alpha participates in assembling CENP-A–containing chromatin at centromeres, helping ensure proper chromosome segregation during cell division.
- It can bind proteins and metal ions and is found in the nucleus and chromatin, particularly at centromeric regions.

Expression:
- MIS18A is expressed in many tissues in both humans and mice, including reproductive tissues such as oocytes and testis.

Orthology:
- MIS18A has conserved orthologs in mouse and other species, reflecting its essential role in chromosome segregation.

External references:
- OMIM: 618137; MGI: 1913828; GeneCards: MIS18A.