Arens–van Dorp synthesis

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Arens–van Dorp synthesis is a classic reaction in organic chemistry. It starts with a lithiated ethoxyacetylene that adds to a ketone to give a propargyl alcohol (an alcohol attached to a nearby triple bond). This product can be further transformed into α,β-unsaturated aldehydes or esters. A common variant, the Isler modification, makes the acetylide in place (in situ) from a β-chlorovinyl ether using lithium amide.